- Strong oral Opioid Analgesic for moderate to severe pain
- Risk of serious respiratory depression
- Among the most abused and diverted prescription medications
- Oxycodone more easily crosses blood brain barrier (lipophilic) and potentiates euphoria
- Immediate Release
- Oxycodone immediate release
- Adults (and over age 12 years) 5-10 mg every 4-6 hours as needed
- Child
- Moderate dose: 0.05 to 0.15 mg/kg/dose (up to 5 mg/dose) every 4-6 hours as needed
- High dose: 0.15 to 0.3 mg/kg/dose (up to 10 mg/dose) every 4-6 hours as needed
- Tabs: 5 mg (scored), 15, 30 mg
- Solution: 5 mg/ml
- Concentrate 20 mg/ml (dissolves sublingually)
-
Acetaminophen and Oxycodone
- Percocet (Oxycodone 5 mg with Acetaminophen 325 mg)
- Dose: 1-2 orally every 6 hours as needed (adults or age over 12 years)
- Roxicet Solution (Oxycodone 5 mg and Acetaminophen 325 mg per 5 ml)
- Dose: Base on Oxycodone dose of 0.05 to 0.15 mg/kg/dose every 4-6 hours up to 5 mg/dose
- Percocet (Oxycodone 5 mg with Acetaminophen 325 mg)
- Controlled-Release (Extended Release)
- Oxycontin 10 mg every 12 hours
- Available in 10 mg, 15 mg, 20 mg, 30 mg, 40, 60 mg, 80 mg sustained release formulations
- Generic in U.S. as of 2016
- Precautions
- Start with short acting Oxycodone and convert to long acting based on pattern of requirements
- Titrate slowly: 80 mg is very high dose and only for Opioid tolerant patients
- Do not break or chew sustained release product (risk of Overdose)
- Sustained release product is intended only for scheduled use (not prn)
- Oxycontin true duration of action approaches 6 hours (instead of 12 hours) in many patients
- Oxycontin may offer no duration benefit over other formulations
- Oxycontin was released as MS Contin (8 hour duration) patent was expiring
- The exaggerated duration may add to misuse and abuse of Opioids
- Art Van Zee (2009) Am J Public Health 99(2): 221–7 +PMID:18799767 [PubMed]
- Respiratory depression or arrest
- Reversal: Naloxone
- Nausea or Vomiting
- Constipation
- Sedation
- Oxycodone Tablet (DailyMed)
- Oxycontin (DailyMed)
- Oxycodone and Acetaminophen (DailyMed)
- Hamilton (2012) Tarascon Pharmacopeia, Jones and Bartlett, Burlington
- Robertson (2005) Harriet Lane Handbook, Mosby, Philadelphia p. 911