Analgesic

Salsalate

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Salsalate, Salflex, Disalcid, Amigesic

  • See Also
  1. Salicylate
  • Indications
  1. FDA approved indications in adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis
  • Contraindications
  1. See Salicylate
  • Mechanism
  1. See Salicylate
  2. Salsalate is a prodrug that is hydrolyzed to the active salicylic acid
  3. Salsalate additional function
    1. Inhibits nuclear factor-kappa B (NF-kB) suppressing gene expression related to inflammation
  • Dosing
  1. Arthritis (OA, RA): 3000 mg/day divided every 8 to 12 hours
  • Adverse Effects
  1. See Salicylate
  • Safety
  1. See Salicylate
  2. Unknown Safety in Lactation
  • Resources
  1. Salsalate (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cef8d6d6-a4e8-4502-8e2f-7cd5129a434c