Analgesic

Diflunisal

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Diflunisal, Dolobid

  • See Also
  1. Salicylate
  • Indications
  1. FDA approved indications in adults
    1. Rheumatoid Arthritis
    2. Osteoarthritis
    3. Analgesic in mild to moderate pain
  • Contraindications
  1. See Salicylate
  • Mechanism
  1. See Salicylate
  2. Difluorophenyl derivate of salicylic acid
  3. Unlike other Salicylates, Diflunisal is not metabolized to salicylic acid
    1. Results in a longer Half-Life than for other Salicylates
  4. As with other Salicylates and NSAIDs, has antipyretic, Analgesic and anti-inflammatory properties
    1. Blocks cyclooxygenase (COX, esp. COX1)
    2. Inhibits conversion of Arachidonic Acid to Prostaglandin precursors
    3. Decreasing Prostaglanding levels results in decreased pain, inflammation and fever
  • Dosing
  1. Diflunisal 250 to 500 mg orally every 8 to 12 hours
  2. Maximum: 1500 mg/day
  • Adverse Effects
  1. See Salicylate
  • Safety
  1. See Salicylate
  2. Avoid in Lactation
  • Resources
  1. Diflunisal (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7a78bb38-14d8-4a90-b883-482d4cebf716