- Most frequent cause of mental Disability in girls (1 in 10,000 to 15,000)
- Regression of previously acquired skills
- Decreased head growth
- Speech loss
- Gait Abnormality
- Loss of purposeful hand movement
- Replaced by repetitive movements (e.g. hand wringing)
- Seizures
- Cerebral Palsy
- Autism
- Angelman Syndrome
- Rett Syndrome Research Trust
- Bollu (2019) Stat Pearls +PMID: 29489169