Pharm
Midodrine
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Midodrine
See Also
Adrenergic Receptor
Alpha Adrenergic Receptor
Sympathetic Nervous System
Sympathomimetic Toxicity
Sympathomimetic
Indications
Autonomic Neuropathy
Mechanism
Alpha
Agonist
: constricts arterioles and veins
Increases peripheral resistance
Efficacy
Study: n=162, PCT
Significantly improved standing BP and symptoms
Reference
Low (1997) JAMA 277:1046-51 [PubMed]
Adverse Effects
Pilomotor reactions
Urinary urgency and retention
Supine
Hypertension
Dosing
Dose: 10 mg PO tid
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