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Tedizolid

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Tedizolid, Sivextro

  • See Also
  1. Linezolid
  • Indications
  1. See Linezolid
  2. Complicated Skin Infections including MRSA
  • Contraindications
  1. Not Approved for use in children
  2. Neutropenia
    1. Tedizolid may be less effective in the absence of adequate Neutrophils
  • Mechanism
  1. See Linezolid
  2. Oxazolidinone Antibiotic (same class as Linezolid)
  3. Ingested as prodrug Tedizolid phosphate and rapidly metabolized in vivo to active Tedizolid
  • Dosing
  • Adult
  1. Give 200 mg oral or IV infused over 1 hour once daily for 6 days
  • Adverse Effects
  1. See Linezolid
  2. Nausea
  3. Vomiting
  4. Diarrhea
  5. Headache
  6. Dizziness
  • Pharmacokinetics
  1. Half-Life 12 hours
  2. Protein bound 70 to 90%
  3. Excreted primarily in the stool
  • Safety
  1. Pregnancy Category C (unknown safety in humans)
  2. Unknown safety in Lactation
  3. Monitoring
    1. No Complete Blood Count monitoring required (unlike Linezolid)
  • Drug Interactions
  1. See Linezolid
  2. No CYP450 interactions
  3. MAO Inhibitor reaction risk (e.g. serotonergic or adrenergic interactions, tyramines)
    1. Tedizolid is a weak, reversible MAO Inhibitor
  4. Other possible interactions (consider holding these agents)
    1. Rosuvastatin
    2. Methotrexate
    3. Topotecan
  • Resources
  1. Tedizolid Tablet (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=75672079-589f-451a-bdbf-eaebcfcc80a9
  • References
  1. (2014) Med Lett Drugs Ther 56(1449):73-5