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Second Generation Anti-anaerobe Cephalosporin

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Second Generation Anti-anaerobe Cephalosporin, Cephamycin, Cefamandole

  • See Also
  1. Second Generation Broad-spectrum Cephalosporin
  2. Cefoxitin
  3. Cefotetan
  4. Cephalosporin
  • Definitions
  1. Cephamycin
    1. Naturally occurring beta lactam Cephalosporins with a 7-methoxy group
    2. Activity against Gram Positive and Gram Negative Bacteria, and resistance to beta lactamases
  • Mechanism
  1. Antibiotics in this group are Cephamycin derivatives
  2. Antibiotic coverage spectrum
    1. Gram Positive activity (but less than Second Generation Broad-spectrum Cephalosporins such as Cefuroxime)
    2. Gram Negative coverage
    3. Anaerobic coverage (e.g. Bacteroides)
  • Indications
  1. Abdominal Surgery prophylaxis
  2. Colorectal surgery prophylaxis
  • Medications
  1. Cefoxitin (Mefoxin)
    1. Give 1-2 grams IM or IV every 6-8 hours
  2. Cefotetan (Cefotan)
    1. Give 1-2 grams IM or IV every 12 hours
  3. Cefamandole
  • References
  1. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins