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Cefotetan

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Cefotetan, Cefotan

  • See Also
  1. Second Generation Anti-anaerobe Cephalosporin
  2. Cefoxitin
  3. Cephalosporin
  • Indications
  1. Abdominal Surgery prophylaxis
  2. Colorectal surgery prophylaxis
  • Mechanism
  1. Antibiotics in this group are Cephamycin derivatives
  2. Antibiotic coverage spectrum
    1. Gram Positive activity (but less than Second Generation Broad-spectrum Cephalosporins such as Cefuroxime)
    2. Gram Negative coverage (similar to Third Generation Cephalosporins)
    3. Anaerobic coverage (e.g. Bacteroides)
  • Dosing
  1. Adult
    1. Typical Dosing
      1. Give 1-2 grams IM or IV every 12 hours
    2. Surgical Prophylaxis
      1. Give 1 to 2 g IV 30 to 60 min before surgery (or for Cesarean Section, after Umbilical Cord clamped)
    3. Renal Dosing
      1. eGFR 10 to 30 ml/min: Give typical dose every 24 hours
      2. eGFR <10 ml/min: Give typical dose every 48 hours
  2. Child (Not FDA approved)
    1. Give 40 to 80 mg/kg/day IV divided every 12 hours
  • Adverse Effects
  1. Hemolytic Anemia
  • Safety
  1. Pregnancy Category B
  2. Safe in Lactation
  • Drug Interactions
  1. Alcohol
    1. Disulfiram reaction (Antabuse-like effect)
  • Resources
  1. Cefotetan (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bd22c66b-8a1c-44c8-b5b6-3ab0ce5c800e
  • References
  1. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins