Pharm

Pyrimethamine sulfadoxine

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Pyrimethamine sulfadoxine, Fansidar, Daraprim

  1. Areas with Chloroquine resistance
  2. Not recommended for routine prophylaxis
  3. Treatment in breakthrough Chloroquine Resistance
  • Preparations
  1. Tablet: 25/500
  • Directions
  1. Taking with food decreases gastric irritation
  • Dosing
  • Prophylaxis
  1. Child
    1. Age 2-11 months: 1/8 tablet PO each week
    2. Age 1-3 years: 1/4 tablet PO each week
    3. Age 4-8 years: 1/2 tablet PO each week
    4. Age 9-14 years: 3/4 tablet PO each week
  2. Adolescent (over age 14 years): 1 tablet PO each week
  3. Adult: 25/500 mg tablet PO each week
  • Dosing
  • Treatment
  1. Adult: 75/1500 mg for 1 dose
  2. Child: Double dose of prophylactic dose