Pharm

Primaquine

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Primaquine

  • Indications
  1. Regions with Plasmodium Vivax transmission
    1. Postexposure prevention for "relapsing" Malaria
    2. Eradication of Malaria liver involvement
  • Contraindications
  1. G6PD Deficiency
    1. Results in acute Hemolysis
  • Directions
  1. May take with or without food
  2. Take with food to reduce gastric irritation
  • Adverse Effects
  1. Abdominal Pain
  2. Nausea
  3. Vomiting
  • Safety
  1. Pregnancy Category C
  2. Safe in children of all ages
  • Dosing
  • Prophylaxis (adults)
  1. Standard
    1. Dose 52.6 mg daily starting 1-2 days before travel and continuing until 7 days after return
  2. Terminal prophylaxis (Following prolonged exposure to P. vivax or P. ovale)
    1. Dose 52.6 mg daily for 14 days on leaving endemic area
  • Dosing
  • Treatment
  1. Adults
    1. Dose: 30 mg base (52.6 mg salt) orally daily for 14 days or
    2. Dose: 45 mg base (78.9 mg salt) orally weekly for 8 weeks
  2. Children
    1. 0.3 mg base (0.5 mg/kg salt) orally daily for 14 days or
    2. 0.9 mg/kg base (1.5 mg/kg salt) orally once weekly for 8 weeks
  • References
  1. Sanford (2016) Am Fam Physician 94(8): 620-7 [PubMed]