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Oxacillin

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Oxacillin, Bactocill

  • See Also
  1. Penicillin
  2. Penicillinase-Resistant Penicillin
  3. Dicloxacillin
  4. Nafcillin
  • Indications
  1. See Penicillinase-Resistant Penicillin
  • Mechanism
  1. See Penicillin
  2. See Penicillinase-Resistant Penicillin
  • Dosing
  1. Adult (or child weight <40 kg)
    1. Give 1 to 2 grams IM or IV every 4 to 6 hours
    2. Use 1.5 to 2 grams IV every 4 hours in Osteomyelitis
  2. Child (weight <40 kg)
    1. Mild to Moderate Infection
      1. Give 100 to 150 mg/kg/day IM or IV divided every 6 hours
    2. Severe Infection
      1. Give 150 to 200 mg/kg/day IM or IV divided every 4 to 6 hours
  3. Newborns (Weight >2 kg)
    1. Age <1 week
      1. Give 25 to 50 mg/kg IV every 8 hours
    2. Age >1 week
      1. Give 25 to 50 mg/kg IM or IV every 6 hours
  • Adverse Effects
  1. Interstitial Nephritis
  2. Liver dysfunction
    1. Occurs with dose >12 g/day
    2. Monitor hepatic panel
  • Safety
  1. Safe in Pregnancy
  2. Safe in Lactation
  • Resources
  1. Oxacillin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8e99d6fe-42ab-44c1-8b51-e4ac7406dbe4
  • References
  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  2. Miller (2002) J Midwifery Womens Health 47(6):426-34 +PMID: 12484664 [PubMed]
  3. Bush (2016) Cold Spring Harb Perspect Med 6(8):a025247 +PMID: 27329032 [PubMed]