-
Cutaneous Candidiasis (topical Nystatin)
- Candida Diaper Dermatitis
- Candidal Intertrigo
-
Oral Candidiasis (Thrush)
- First-line agent
-
Yeast Vaginitis
- Other medications are preferred
- Dermatophytes or tinea fungal infections (ineffective)
- Macrolide Antifungal and Polyene Antifungal (as is Amphotericin B)
- Like Amphotericin B, Nystatin binds sterols in fungal plasma membranes, resulting in fungal cell leak and death
- Synthesized by the Bacteria streptomyces noursei, Staphylococcus Aureus, and other Streptomyces species
- Three biologically active components (A1, A2, A3) form the Nystatin complex
- Topical Nystatin (100,000 units/gram)
- Available as a cream, ointment or powder
- Oral
- Suspension: 100,000 units/ml
- Film-coated tablets: 500,000 units
- Topical for Cutaneous Candidiasis (topical Nystatin)
- Apply 2 to 3 times daily
- Adults
- Pastilles: 200,000 unit lozenge four times daily for 14 days
- Swish and swallow: 500,000 units (5 ml) four times daily for 14 days
- Tablets: Two 500,000 unit tablets three times daily for 14 days
- Child
- Swish and swallow 500,000 units (5 ml) orally four times daily for 14 days
- Infant
- Suspension (100,000 u/ml): Swab 1 ml on each cheek four times daily for 14 days
- Decrease dose in Preterm or low-birth weight infants to 0.5 ml/cheek
- Avoid feeding infant for 5 to 10 minutes after dose
- Nystatin vaginal tablet (100,000 unit) PV daily for 14 days
- Nystatin ointment (100,000 units/g)
- Ointments are less irritating than creams
- Pregnancy category C
- Considered safe in Lactation
- When taken orally, Nystatin is not absorbed
- Excreted unchanged in feces
- Nystatin Suspension (DailyMed)
- Nystatin Tablet (DailyMed)
- Nystatin Cream (DailyMed)