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Meropenem Vaborbactam

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Meropenem Vaborbactam, Vabomere

  • See Also
  1. Carbapenem
  2. Meropenem
  • Indications
  1. See Carbapenem
  2. Meropenem Vaborbactam is indicated in complicated UTI where other options have been exhausted due to Antibiotic Resistance
  • Mechanism
  1. See Carbapenem
  • Dosing
  1. Standard Adult Dosing
    1. CrCl >=50 ml/min: 4 g IV every 8 hours administered over 3 hours
  2. Renal Dosing
    1. CrCl 30 to 49 ml/min: 2 g IV every 8 hours administered over 3 hours
    2. CrCl 15 to 29 ml/min: 2 g IV every 12 hours administered over 3 hours
    3. CrCl <15 ml/min: 1 g IV every 12 hours administered over 3 hours
      1. Administer after Hemodialysis
  • Drug Interactions
  1. See Carbapenem
  • Adverse Effects
  1. See Carbapenem
  2. Thrombocytopenia
    1. May oocur with Meropenem (Merrem) in patients with renal dysfunction
  • Resources
  1. Meropenem Vaborbactam (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e237fd0f-3050-42a3-b43e-b6fb4824e93d
  • References
  1. LiverTox (2017), accessed online 1/2/2023
    1. https://www.ncbi.nlm.nih.gov/books/NBK548705/
  2. Hamilton (2020) Tarascon Pharmacopeia
  3. (2012) Presc Lett, Resource #231205, Comparison of Carbapenem Antibiotics
  4. Zhanel (2007) Drugs: 67(7): 1027-52 [PubMed]