Pharm

Mebendazole

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Mebendazole, Emverm, Vermox

  • Medications
  1. Chewable Tablets: 100 mg
    1. In U.S., Vermox was original trade name (in 2016 was rebranded as Enverm)
  • Indications
  1. Pinworm
  2. Roundworm
  3. Whipworm
  4. Hookworm
  • Mechanism
  1. Synthetic benzimidazole derivate
  2. Inhibits Helminth (worm) reproduction and survival
    1. Blocks microtubule formation (polymerization) in cytoplasm
    2. Blocks Glucose uptake and depletes Helminth glycogen stores
    3. Results in reduced ATP and Helminth death
  • Dosing
  • Adults and Children
  1. Doses for adults and children are the same
  2. Pinworm
    1. Mebendazole 100 mg orally for a single dose, and repeat in 2 weeks
  3. Roundworm, Hookworm or Whipworm
    1. Mebendazole 100 mg orally twice daily for 3 days OR
    2. Mebendazole 500 mg orally twice daily for one dose (off label)
  • Safety
  1. Unknown safety in first trimester (may be used in later pregnancy)
  2. Considered safe in Lactation
  • Resources
  1. Mebendazole (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8c46363-f739-4f6e-bca8-1ce5e8d3f78d