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Erythromycin Lactobionate

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Erythromycin Lactobionate, Erythrocin IV

  • See Also
  1. Erythromycin
  2. Macrolide
  • Indications
  1. See Erythromycin
  • Mechanism
  1. See Macrolide
  • Adverse Effects
  1. See Erythromycin
  • Drug Interactions
  1. See Macrolide
  • Dosing
  1. Dose: 15 to 20 mg/kg/day divided every 6 hours IV
  2. Maximum: 4 grams/day
  • Adverse Effects
  1. See Erythromycin
  2. Venous Irritation
    1. Administer solution in diluted form and slowly
  3. Myasthenia Gravis exacerbation
  4. Hypertrophic Pyloric Stenosis (age <45 days)
  5. QT Prolongation
    1. Class effect with Macrolides
    2. Three fold increased risk of Sudden Cardiac Death while on Azithromycin
    3. Higher risk with known QTc Prolongation, Hypokalemia, Hypomagnesemia, Class IA or III Antiarrhythmics
    4. Ray (2013) N Engl J Med 366(20): 1881-90 [PubMed]
  • Drug Interactions
  1. Strong CYP3A4 Inhibitor
    1. Numerous Drug Interactions
    2. Serious interactions resulting in death have occurred
  2. Warfarin
    1. May increase INR
  • Safety
  1. Pregnancy Category B
  2. Considered safe in Lactation
  • Resources
  1. Erythromycin Lactobionate (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a96c405f-bd70-4bb4-719e-ac6a79dcc213