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Cefazolin

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Cefazolin, Ancef

  • See Also
  1. First Generation Cephalosporin
  2. Cephalexin
  3. Cefadroxil
  4. Cephalosporin
  • Indications
  1. See First Generation Cephalosporin
  2. Skin and Soft Tissue Infection
  3. Surgical Prophylaxis
  4. Endocarditis
  5. Uncomplicated Urinary Tract Infection
  6. SBE Prophylaxis
  • Mechanism
  1. See First Generation Cephalosporin
  • Dosing
  • Adult
  1. Mild to Moderate Infections
    1. Give 0.5 to 1 g IM or IV every 6 to 8 hours
  2. Severe Infections
    1. Give 1 to 1.5 g IM or IV every 6 hours
  3. Loading Dose protocol
    1. Give 2 g IM or IV, then 1 g every 6 to 8 hours
  4. Renal Dosing
    1. eGFR 35 to 54 ml/min: Dose every 8 hours
    2. eGFR 10 to 35 ml/min: 50% of typical dose every 12 hours
    3. eGFR <10 ml/min: Give first typical dose, then 50% of typical dose every 18 to 24 hours
  • Dosing
  • Child (age >1 month)
  1. Mild to Moderate Infections (Typical Dosing)
    1. Give 25 to 50 mg/kg/day divided every 6 to 8 hours
  2. Severe Infections
    1. Give 100 mg/kg/day divided every 6 to 8 hours
  3. Maximum: 2 grams per dose
  4. Renal Dosing
    1. eGFR 40 to 70 ml/min: 60% of typical dose every 12 hours
    2. eGFR 20 to 40 ml/min: 25% of typical dose every 12 hours
    3. eGFR 5 to 20 ml/min: Give first typical dose, then 10% of typical dose every 24 hours
  • Safety
  1. Pregnancy Category B (All Trimesters)
  2. Safe in Lactation
  • Resources
  1. Cefazolin (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d91a8d13-99a0-4d87-88dc-71cbd37922b4
  • References
  1. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia