Pharm
Anidulafungin
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Anidulafungin
, Eraxis
See Also
Antifungal Medication
Topical Antifungal
Caspofungin
Micafungin
Indications
Conditions
Candidemia (systemic
Candidiasis
)
Esophageal Candidiasis
Activity
Candida species (including those resistant to
Azole Antifungal
s)
Aspergillus
species (some activity)
Contraindications
Resistant organisms
Cryptococcus species
Trichosporon species
Dimorphic Fungi (e.g. Coccidioides, Blastomyces, Histoplasma)
Mechanism
Echinocandin
(
Cyclic Lipopeptide
)
Inhibits synthesis of beta-(1,3)-D-Glucan a key cell wall component
Semi-synthetic derived from the fermentation product of the fungue
Aspergillus
nidulans
Dosing
Adult
Candidemia (systemic
Candidiasis
)
Load: 200 mg IV (infused at <1.1 mg/min) on day 1
Next 100 mg IV (infused at <1.1 mg/min) daily for at least 14 days after the last positive culture
Esophageal Candidiasis
Load: 100 mg IV (infused at <1.1 mg/min) on day 1
Next 50 mg IV (infused at <1.1 mg/min) daily for at least 14 days (and at least 7 days after symptoms have resolved)
Dosing
Child (Off-label)
Candidemia (systemic
Candidiasis
) for age 1 month and older
Load: 3 mg/kg IV (infused at <1.1 mg/min) on day 1
Next 1.5 mg/kg IV (infused at <1.1 mg/min) daily for at least 14 days after the last positive culture
Adverse Effects
Well tolerated overall
Similar adverse effects to
Caspofungin
and
Micafungin
Anaphylaxis
has occurred
Histamine
reactions (
Pruritus
,
Urticaria
)
Occurs with more rapid infusion (avoid infusion rates >1.1 mg/min)
Safety
Unknown safety in
Lactation
Pregnancy Category C
Teratogen
ic in animals (and insufficient data in humans)
Pharmacokinetics
No renal dose adjustment needed
Does not require dose adjustment in hepatic failure (unlike
Caspofungin
and
Micafungin
)
Drug Interactions
No significant
Drug Interaction
s
Resources
Anidulafungin (DailyMed)
https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a88d9010-55fb-4a02-baff-042cd27688ea
References
Hamilton (2020) Tarascon Pocket Pharmacopoeia
(2012) Med Lett Drugs Ther 10(120): 61-8 [PubMed]
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