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Cholera Vaccine
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Cholera Vaccine
, Lypholized CVD 103-HgR, Vaxchora, PaxVax
Indications
Prevention of
Vibrio Cholera
O1 in adults travelling to
Cholera
-affected areas
Travelers visiting friends and relatives
Health care personnel
Cholera
outbreak response workers
Extended travel to
Cholera
affected areas
Preparations
Lypholized CVD 103-HgR (Vaxchora, PaxVax)
Single dose, live attenuated, oral Cholera Vaccine
Only FDA approved Cholera Vaccine in U.S. (approved in 2016)
Efficacy beyond 3 months is not known as of late 2017
Avoid use of antibiotics in the 14 days preceding Cholera Vaccine
Delay starting
Chloroquine
for at least 10 days after oral Cholera Vaccine
Delay taking oral
Typhoid Vaccine
by at least 8 hours after oral Cholera Vaccine
Likely safe in
HIV Infection
(but lower seroconversion rate)
Like safe in pregnancy as no systemic absorption (however
Vaccine
is shed for 7 days)
Killed Cholera Vaccine
Older intradermal
Vaccine
, 0.2 ml IM given at time 0, 1-4 weeks and then every 6 months as needed
Protection of 30-50% lasts only 6 months
Safe in
Human Immunodeficiency Virus
(HIV)
Immunization in HIV
Do not use in pregnancy
See
Vaccination in Pregnancy
References
Wong (2017) MMWR 66(18): 482-5 [PubMed]
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