Pharm

Ximelagatran

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Ximelagatran, Exanta, Exarta

  • See Also
  1. Direct Thrombin Inhibitor
  2. Dabigatran (Pradaxa)
  3. Argatroban
  4. Bivalirudin
  5. Desirudin
  • Background
  1. No longer available (off market in U.S.) due to hepatotoxicity
  2. Listed for historical reasons only
  • Mechanism
  1. Direct Thrombin Inhibitor
  1. Warfarin intolerant
  2. Patients with high risk of Intracranial Hemorrhage
  • Efficacy
  1. Advantages
    1. As effective as Warfarin with INR 2-3
    2. Ximelagartan does not require monitoring
    3. Ximelagartan has fewer bleeding complications
  2. Disadvantages
    1. Expensive
    2. Myocardial Ischemia risk
    3. Risk of severe liver toxicity
  • Dosing
  1. Studies used fixed dose of 36 mg bid
  • References
  1. Albers (2005) JAMA 293:690-8 [PubMed]
  2. Olsson (2003) Lancet 362:1691-8 [PubMed]