Pharm

Desirudin

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Desirudin, Ipravask

  • See Also
  1. Direct Thrombin Inhibitor
  2. Dabigatran (Pradaxa)
  3. Argatroban
  4. Bivalirudin
  • Indications
  1. DVT Prophylaxis after hip surgery
  • Mechanism
  1. Hirudin Direct Thrombin Inhibitor
    1. Bivalent peptide derivatives from Salivary Gland of medicinal leaches
  • Dosing
  1. DVT Prophylaxis after hip surgery
    1. Administer 15 mg SQ every 12 hours after hip surgery
    2. GFR 31 to 60 ml/min
      1. Reduce dose to 5 mg SQ every 12 hours
    3. GFR <=30 ml/min
      1. Reduce dose to 1.7 mg SC every 12 hours
      2. Avoid repeat dosing (risk of Anaphylaxis)
  • Adverse Effects
  1. Major Bleeding
  2. Allergic Reaction
    1. Serious Allergic Reactions including Anaphylaxis may occur with Hirudins
    2. Highest risk on Hirudin re-exposure or in GFR <30 ml/min
  • Safety
  1. Pregnancy Category C
  2. Unknown safety in Lactation
  • Resources
  1. Desirudin (FDA)
    1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021271s006lbl.pdf