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Tenecteplase

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Tenecteplase, TNKase, TNK tPA

  • See Also
  1. Thrombolytic
  2. Thrombolysis in Massive Pulmonary Embolism
  3. Thrombolysis in Cerebrovascular Accident
  4. Thrombolysis in ST Elevation Myocardial Infarction
  5. ST Elevation MI (STEMI)
  6. Alteplase (t-PA)
  • Indications
  1. ST Elevation Myocardial Infarction (STEMI)
    1. See Thrombolysis in ST Elevation Myocardial Infarction
  2. Acute Ischemic Cerebrovascular Accident (off label)
    1. See Thrombolysis in Cerebrovascular Accident
    2. Tenecteplase use for CVA (instead of t-PA) has become more common due to its single, rapid IV dosing
  • Mechanism
  1. Recombinant Tissue Plasminogen Activator (rt-PA)
    1. Serine protease that binds Fibrin and converts Fibrin-bound plasminogen to plasmin
      1. TNK has a higher Specificity for Fibrin than Alteplase (t-PA)
    2. Plasmin breaks down both Fibrin and Fibrinogen to Fibrin
      1. Fibrin Degradation Products result, which in turn also act to inhibit Fibrin formation
  • Dosing
  1. ST Elevation Myocardial Infarction (STEMI)
    1. Give a single IV bolus dose over 5 seconds
    2. Once reconstituted, IV solution must be used within 8 hours
    3. Weight <60 kg: 30 mg IV
    4. Weight 60 to 69 kg: 35 mg IV
    5. Weight 70 to 79 kg: 40 mg IV
    6. Weight 80 to 89 kg: 45 mg IV
    7. Weight >=90 kg: 50 mg IV
  2. Cerebrovascular Accident (off-label)
    1. Give a single 0.25 mg/kg (up to 25 mg) IV over 5 to 10 seconds
  • Pharmacokinetics
  1. Half-Life: 20 minutes (contrast with 5 minutes for t-PA)
  • Adverse Effects
  • CVA Protocol
  1. Intracerebral Hemorrhage (ICH)
    1. Early data suggested a possible higher risk of ICH compared with t-PA
    2. However, ICH data was based on higher doses (0.4 mg/kg) than current dosing (0.25 mg/kg)
    3. Later 2023 studies at lower dose (0.25 mg/kg) supported the use of TNK over t-PA (see efficacy below)
    4. Marcolini and Swaminathan (2023) Neurocritical Care Mailbag, EM:Rap, December, accessed 12/1/2023
    5. Kvistad (2022) Lancet Neurol 21(6):511-9 +PMID: 35525250 [PubMed]
    6. Qureshi (2023) J Stroke Cerebrovasc Dis 32(2):106898 +PMID: 36493706 [PubMed]
  • Safety
  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation
  • Efficacy
  • CVA
  1. Lower mortality and Intracerebral Hemorrhage than with t-PA
    1. Murphy (2023) Ann Emerg Med 82(6):720-8 +PMID: 37178103 [PubMed]
  2. Similar outcomes (including Intracerebral Hemorrhage) as with t-PA
    1. Yogendrakumar (2023) Neurology 100(18):e1900-11 +PMID: 36878701 [PubMed]
  • Resources
  1. Tenecteplase (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=739a3c53-caf6-40d6-a6af-84ce733a948b