Pharm

Plant Alkaloid Chemotherapy

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Plant Alkaloid Chemotherapy

  • Mechanism
  1. Vinca alkaloids
    1. Inhibits mitosis (metaphase arrest)
    2. Cause disassembly of microtubules
  2. Podophyllotoxins
    1. Block cells in S-G2 phase of cell cycle
    2. DNA degradation
    3. Nucleoside transport inhibition
    4. Mitochondrial electron transport inhibition
  • Agents
  1. Periwinkle Plant (Vinca rosea) derivative
    1. Vinblastine (Velban)
    2. Vincristine (Oncovin)
  2. Mayapple plant (Podophyllum peltatum) derivative
    1. Etoposide (VP-16)
    2. Teniposide (VM-26)