Hand Foot Syndrome in Sickle Cell Anemia


Hand Foot Syndrome in Sickle Cell Anemia, Dactylitis in Sickle Cell Anemia

  • Epidemiology
  1. Often the first vaso-Occlusion crisis finding in young children (as early as 6 months of age)
  2. Occurs in up to 50% of children with Sickle Cell Anemia by the age of 2 years
  3. Rare over age 4 years old
  • Pathophysiology
  1. Not to be confused with Hand Foot Syndrome that occurs with certain Chemotherapy agents in non-sickle disease
  2. Occurs in Sickle Cell Anemia with vaso-Occlusion
  3. Caused by infarction of Bone Marrow
    1. Metacarpal or Metatarsal Bones and phalanges
  • Symptoms
  1. Painful swelling and tenderness of either the hand or foot
  2. Digits may appear mildly erythematous
  • Signs
  1. Low grade fever (variably present)
  • Differential Diagnosis
  • Course
  1. Resolves spontaneously within 1 week
  • References
  1. Welsh and Welsh (2016) Crit Dec Emerg Med 30(11): 15-23