Renal

Renal Manifestations of HIV

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Renal Manifestations of HIV, HIV Related Renal Complications, HIV-Relared Kidney Disease, Kidney Disease Associated with AIDS

  • Causes
  • Glomerular Disease
  • Causes
  • Renal Tubular Disease
  1. Acute Kidney Injury
  2. Fanconi's Syndrome (Proximal Tubule Injury)
  3. Diabetes Insipidus
  4. Crystal Nephropathy
  5. Drug induced Renal toxicity
    1. See Nephrotoxic Drug
    2. Amphotericin B
    3. Foscarnet
    4. Pentamidine
    5. Trimethoprim Sulfamethoxazole
    6. NSAIDs
    7. Tenofovir disoproxil Fumarate (TDF)
      1. Causes proximal tubule dysfunction (e.g. Hypophosphatemia) and decreased Renal Function
      2. Avoid if GFR <60 ml/min and discontinue if GFR falls more than 25% or <60 ml/min
      3. May safely use Tenofovir Alafenamide as alternative (less nephrotoxic)
  • Causes
  • Other HIV Related Renal Disorders
  1. Interstitial Nephritis
  2. Fluid and Electrolyte abnormalities
    1. SIADH and Hyponatremia common due to occult infection
  • References
  1. Baloor (2018) Exam Preparatory Manual for Undergraduates Medicine, Jaypee Brothers, India, p. 240
  2. Chu (2017) Am Fam Physician 96(3): 161-9 [PubMed]