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Emtricitabine

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Emtricitabine, Truvada, FTC, Emtriva, Coviracil, Descovy

  • See Also
  1. Anti-Retroviral Therapy
  2. Nucleoside Reverse Transcriptase Inhibitor
  3. HIV Preexposure Prophylaxis
  • Preparations
  1. Emtricitabine (Emtriva, Coviracil)
  2. Emtricitabine with Tenofovir (Truvada TDF or Descovy TAF)
  • Mechanism
  1. Nucleoside Reverse Transcriptase Inhibitor
  • Adverse Effects
  • Emtricitabine alone
  1. See nRTI for adverse effects attributed to the class
  2. Minimal specific adverse effects and well tolerated
  3. Hyperpigmentation of palms and soles
  4. Hepatitis B infection flares on withdrawal of medication
  • Adverse Effects
  • Emtricitabine with Tenofovir (Truvada, Descovy)
  1. See Tenofovir
  2. Start-up syndrome (Nausea, Abdominal Pain, Flatulence, Headache) which typically resolves after the first month
  3. Hepatitis B Virus flare
    1. Associated with abrupt cessation of Antiretroviral therapy
  4. Acute Renal Failure
    1. Risk when Truvada is combined with multiple dose or high dose NSAIDs
    2. May be less risk with Descovy (uses Tenofovir TAF instead of TDF)
  • Protocol
  • HIV Prevention
  1. See HIV Preexposure Prophylaxis
  • References
  1. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
  2. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]