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Abacavir

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Abacavir, Ziagen

  • See Also
  1. Anti-Retroviral Therapy
  2. Nucleoside Reverse Transcriptase Inhibitor
  • Contraindications
  1. HLA-B*5701 positive state (screen in advance of starting)
    1. Associated with life-threatening Hypersensitivity
  • Mechanism
  1. Nucleoside Reverse Transcriptase Inhibitor
  • Dosing
  1. Abacavir 300 mg PO bid
  • Precautions
  1. Do not use unless patient is negative for HLA-B5701
    1. Risk of Hypersensitivity Reaction if HLA-B5701 positive
    2. Lucas (2007) J Antimicrob Chemother 59(4):591-3 +PMID:17317695 [PubMed]
  • Adverse Effects
  1. Hypersensitivity (3%)
    1. Presents with Fever and Rash
    2. Associated with HLA-B*5701 positive state
    3. Mean onset 11 days after start
    4. Lethal reaction if restarted after reaction (50%)
    5. Never rechallenge Abacavir after reaction
  2. Cardiovascular risk
    1. Unclear association is being investigated
  1. Phone: 1-800-270-0425
  • References
  1. (1998) Med Lett Drugs Ther 40(1041):115 [PubMed]
  2. (2009) Treat Guidel Med Lett 7(78): 11-22 [PubMed]
  3. Reust (2011) Am Fam Physician 83(12): 1443-51 [PubMed]