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Tissue-selective Estrogen Complex
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Tissue-selective Estrogen Complex
, TSEC, Bazedoxifene, Duavee
See Also
Estrogen Replacement Therapy
Definitions
Tissue-selective Estrogen Complex (TSEC)
Combination of
Estrogen
with a
Selective Estrogen Receptor Modulator
(
SERM
)
Indications
Tissue-selective Estrogen Complex (TSEC)
Estrogen Replacement Therapy
in patients with an intact
Uterus
Background
Duavee is the first Tissue-selective Estrogen Complex or TSEC (released in 2014)
Duavee is a combination of
Conjugated Estrogen
with Bazedoxifene (
SERM
)
Alternative to combination
Estrogen
with
Progesterone
Efficacy
Duavee (
Conjugated Estrogen
AND Bazedoxifene)
Unclear role outside of cases of
Estrogen Replacement
with intact
Uterus
, in which
Progesterone
is contraindicated
SERM
s add potential for increased adverse effects with no added benefit when used in combination with
Estrogen
No additional bone protection in
Osteoporosis
Effective in decreasing vasomotor symptoms
Significantly reduces vasomotor symptoms without affecting
Breast
tissue, endometrium or VTE or
Cardiac Risk
Lello (2017) Int J Endocrinol 2017:5064725 +PMID: 29358948 [PubMed]
Medications
Duavee (
Conjugated Estrogen
0.45 mg with Bazedoxifene 20 mg)
References
(2014) Presc Lett 21(3)
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