Pharm
Potassium Competitive Acid Blocker
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Potassium Competitive Acid Blocker
, PCAB, Vonoprazan, Voquezna, Takecab
Mechanism
Potassium Competitive Acid Blocker (PCAB) blocks both active and resting proton pumps
Activity onset within hours regardless of timing with meals
Contrast with
Proton Pump Inhibitor
s
Block only active proton pumps
Full action is delayed up to 7 days
Best taken 30 to 60 minutes before a meal
Preparations
Vonoprazan Fumarate (Takecab)
High Dose: 20 mg orally twice daily
Helicobacter Pylori
Management
Moderate Dose: 20 mg orally daily
Gastric Ulcer
or
Duodenal Ulcer
Gastroesophageal Reflux
(
GERD
)
Low Dose: 10 mg orally daily
Reflux Esophagitis
prevention
Aspirin
or
NSAID
induced
Peptic Ulcer
prevention
Preparations
Helicobacter Pylori
Management
Background
Lower efficacy than quadruple therapy
At $800 in 2022, the cost is four fold higher than standard quadruple therapy
Voquezna Dual Pak (Vonoprazan,
Amoxicillin
)
Voquezna Triple Pak (Vonoprazan,
Amoxicillin
,
Clarithromycin
)
References
Echizen (2016) Clin Pharmacokinet 55(4):409-18 +PMID: 26369775 [PubMed]
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