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Prucalopride

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Prucalopride, Motegrity

  • See Also
  1. Chronic Constipation
  • Indications
  1. Chronic Idiopathic Constipation
  2. Constipation Dominant Irritable Bowel Syndrome
  • Contraindications
  1. Children
  2. Renal Failure
  3. Mechanical Bowel Obstruction
  • Mechanism
  1. Selective Serotonin 4 Receptor Agonist (5HT4 Agonist)
    1. Prokinetic that stimulates colonic peristalsis
  • Dosing
  1. Take 2 mg orally once daily
  2. Decrease dose to 1 mg/day in eGFR <30 ml/min
  • Adverse Effects
  1. Headache
  2. Nausea
  3. Diarrhea
  4. Abdominal Pain
  • Safety
  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation
  • Resources
  1. Prucalopride (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bca1e4c6-4b2b-4876-8ab3-654629c4ff1b
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 98
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia