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Mineral Oil

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Mineral Oil, Kondremul, Mineral Oil Enema

  • See Also
  1. Emollient Laxative
  2. Laxative
  3. Constipation
  4. Functional Constipation
  5. Pediatric Constipation
  6. Neonatal Constipation
  • Indications
  1. Chronic Constipation
  • Contraindications
  1. Risk of Aspiration Pneumonia (lipoid Pneumonia)
  2. Malabsorption
  3. Age < 12 months
  • Mechanism
  1. Lubricant Laxative
    1. Mineral Oil coats the bowel and stool with a waterproof film
    2. Decreases bowel absorption of water
  • Precautions
  1. Aspiration risk
  • Dosing
  1. General
    1. Give chilled in juice to maximize tolerability
    2. Coadminister Multivitamin daily if used chronically
  2. Child Dose (over 18 months of age)
    1. Oral Dose
      1. Give 1 to 3 ml/kg/day divided daily to twice daily
      2. Used in maintenance of bowel regimen
      3. Maximum: 90 ml/day
    2. Rectal Dose (Mineral Oil Enema)
      1. Age 2 to 11 years: Give 30 to 60 ml per Rectum once daily
      2. Age 12 to 18 years: Give 60 to 150 ml per Rectum once daily
    3. Disimpaction
      1. Give 15-30 ml per age in years up to 240 ml/day
      2. May repeat daily for 3-4 days
  3. Adult Dose (or age > 12 years)
    1. Low Dose
      1. Take 5 to 45 ml orally in the evening
    2. High Dose
      1. Take 30 to 90 ml as needed
  • Pharmacokinetics
  1. Onset of action
    1. Oral: 6 to 8 hours
    2. Rectal: 2 to 15 minutes
  • Adverse Effects
  1. Abdominal cramping
  2. Lipoid pneumonitis if aspirated
    1. Avoid bedtime dosing
  3. Anal irritation and leakage
  4. Vitamin malabsorption
  • Resources
  1. Mineral Oil
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fe39836b-97db-4472-a1d9-582152443dfa
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 94
  2. (2023) Management of Constipation, Presc Lett, #390108