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Amitiza

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Amitiza, Lubiprostone

  • See Also
  1. Gastrointestinal Opioid Antagonist (e.g. Methylnatrexone, Movantik, Naloxegol, Nalmedemedine)
  2. Opioid Adverse Effect Management
  3. Bowel Regimen in Chronic Narcotic Use
  • Dosing
  1. Irritable Bowel Syndrome with Constipation: 8 mcg orally twice daily
  2. Chronic Constipation: 24 mcg orally twice daily
  • Adverse Effects
  1. Nausea (with 24 mcg dose)
  2. Diarrhea (with 24 mcg dose)
  3. Chest Pain or Dyspnea
    1. Follows dose within 1 hour
    2. Resolves within 3 hours
  • Disadvantages
  1. Low efficacy in Irritable Bowel Syndrome with Constipation: Only 14% respond
  2. Expensive: $200 per month
  • Mechanism
  1. ClC(2) chloride channel opener
  • References
  1. Chang (2006) Curr Treat Options Gastroenterol 9(4):314-23 [PubMed]