Pharm

Intraocular Alpha-2 Adrenergic Agonist

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Intraocular Alpha-2 Adrenergic Agonist, Intraocular Alpha-Adrenergic, Apraclonidine, Lopidine, Brimonidine, Alphagan, Lumify, Mirvaso

  • See Also
  1. Open Angle Glaucoma
  • Indications
  1. Open Angle Glaucoma
  2. Rosacea
  • Mechanism
  1. Decrease Aqueous Humor production and increases outflow (lowers IOP 20 to 25%)
  • Medications (purple cap)
  1. Apraclonidine (Lopidine)
  2. Brimonidine (Alphagan)
    1. Available as combination with Brinzolamide (Simbrinza)
    2. Mirvaso (Brimonidine gel)
      1. Indicated for Eye Redness due to Rosacea
    3. Lumify (OTC Brimonidine 0.025%) released in 2018
      1. Marketed as OTC to reduce Eye Redness
      2. No proof that it is more effective than OTC ocular Decongestants (e.g. visine) and more expensive
      3. Evaluate Eye Redness for underlying cause instead
      4. (2018) presc lett 25(6): 35 [PubMed]
  • Drug Interactions
  1. Monoamine Oxidase Inhibitors
  • Adverse Effects
  1. Eye itching, burning or stinging
  2. Dry Mouth
  • Efficacy
  1. Less effective than Intraocular Beta Blocker and Intraocular Prostaglandin
  • References
  1. Harris (2023) Am Fam Physician 107(3): 238-46 [PubMed]