Pharm

Palforzia

search

Palforzia, Peanut Allergen Powder

  • See Also
  1. Food Allergy
  2. Immunotherapy
  • Indications
  1. Peanut Allergy Desensitization in ages 4 to 17 years old
    1. Goal to reduce severity of reactions (NOT to reintroduce peanuts into diet)
    2. Alternative to peanut oral Immunotherapy (performed by allergists)
  • Contraindications
  1. Severe Asthma
  2. Eosinophilic Esophagitis (or other Eosinophilic gastrointestinal disease)
  3. Anaphylaxis for any reason within the last 60 days
  • Efficacy
  1. Following 1 year of Desensitization, two thirds of children are expected to tolerate 2 peanuts without reaction
  • Precautions
  1. Peanut free diet must be followed regardless of Desensitization
  2. Keep Epinephrine Autoinjector nearby (reactions will be more common during Desensitization)
  • Disadvantages
  1. Cost: $890 per month ($3000 for full one year course)
  2. Must be in office to start medication and at each titration up in dose
  3. Restart in clinic if >3 doses missed
  • Dosing
  1. Risk Evaluation and Mitigation Strategy (REMS) required for prescribers
  2. Taken daily and gradually increasing doses
  • Adverse Effects
  1. Abdominal Pain (26%)
  2. Allergic symptoms
    1. Throat irritation (9.3%)
    2. Oral Pruritus (8.7%)
  • References
  1. (2020) Presc Lett 27(10): 58