- Allergic Rhinitis
- Urticaria
- Serotonin Syndrome (not FDA approved)
- Appetite Stimulant (not FDA approved)
- See Antihistamine
- H1 Receptor Antagonist (First Generation Antihistamine)
- Cyproheptadine is an synthetic methyl-piperidine derivative with moderate Anticholinergic activity
- Cyproheptadine also has antiserotinergic activity
- Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
- Deaths have occurred in younger children related to Anticholinergic Toxicity
- Adult (age >14 years): Start 4 mg orally three times daily (maximum 32 mg/day)
- Child (age 7 to 14 years): Start 4 mg orally three times daily (maximum 16 mg/day)
- Child (age 2 to 6 years): Start 2 mg orally three times daily
- See Serotonin Syndrome
- Start 12 mg orally for first dose
- Next: 2 mg orally every 2 hours until symptoms resolve
- Next 8 mg every 6 hours until syndrome completes
- See Antihistamine
- See Anticholinergic Toxicity
- Sedation
- Pregnancy category B
- Avoid in Lactation
- Cyproheptadine (DailyMed)
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia