Pharm

Carbinoxamine

search

Carbinoxamine, Palgic, Ryvent

  • See Also
  1. Antihistamine
  2. Anticholinergic Toxicity
  • Indications
  1. Allergic Rhinitis
  2. Vasomotor Rhinitis
  3. Urticaria
  • Mechanism
  1. See Antihistamine
  2. H1 Receptor Antagonist
  3. Carbinoxamine Maleate is an Ethanolamine First Generation Antihistamine with high Anticholinergic activity
  • Precautions
  1. Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
    1. Deaths have occurred in younger children related to Anticholinergic Toxicity
  • Dosing
  • Regular Release Formulation
  1. Adult: 4 to 8 mg orally three to four times daily
  2. Child age 2 to 3 years: 2 mg orally three to four times daily
  3. Child age 3 to 6 years: 2 to 4 mg orally three to four times daily
  4. Child age 2 to 3 years: 4 to 6 mg orally three to four times daily
  • Adverse Effects
  1. See Antihistamine
  2. See Anticholinergic Toxicity
  3. Sedation
  • Safety
  1. Pregnancy category C
  2. Avoid in Lactation
  • Resources
  1. Carbinoxamine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1edca669-8879-408a-b09c-259e363dd95c
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia