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Clemastine

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Clemastine, Tavist

  • See Also
  1. Antihistamine
  2. Anticholinergic Toxicity
  • Indications
  1. Allergic Rhinitis
  2. Urticaria
  3. Angioedema
  • Mechanism
  1. See Antihistamine
  2. H1 Receptor Antagonist
  3. Clemastine is an Ethanolamine First Generation Antihistamine with strong Anticholinergic activity
  • Precautions
  1. Although FDA approved for children, FDA does not recommend routine Antihistamine use age <4 years
    1. Deaths have occurred in younger children related to Anticholinergic Toxicity
  • Medications
  1. Clemastine Fumarate (tablets) at 1.34 mg are equivalent to Clemastine base 1 mg
  1. Adult (age >=12 years): 1.34 mg orally twice daily (maximum 8.04 mg/day)
  2. Child (age 6 to 11 years): 0.67 mg orally twice daily (maximum 4.02 mg/day)
  1. Adult (age >=12 years): 2.68 mg orally two to three times daily (maximum 8.04 mg/day)
  2. Child (age 6 to 11 years): 1.34 mg orally twice daily (maximum 4.02 mg/day)
  • Adverse Effects
  1. See Antihistamine
  2. See Anticholinergic Toxicity
  3. Sedation
  • Safety
  1. Pregnancy category B
  2. Avoid in Lactation
  • Resources
  1. Clemastine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=14aaadca-7d86-47e8-8483-6e05d456949d
  • References
  1. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 146-7
  2. Hamilton (2020) Tarascon Pocket Pharmacopoeia