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Inflammatory Linear Verrucous Epidermal Nevus

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Inflammatory Linear Verrucous Epidermal Nevus, ILVEN

  • Pathophysiology
  1. Variant of Dermal Nevus (mole)
  2. Benign overgrowth of epidermal cells
  3. Recurrent inflammatory changes resulting in Eczematous or Psoriasis-like changes
  4. Lesions follow lines of normal Embryologic skin cell migration (blaschko lines)
  5. Likely result from somatic mutations with genetic mosaicism
  • Epidemiology
  1. Presents in newborns and young children
  2. Female gender predominance
  3. Primarily sporadic but may be genetic
  • Findings
  1. Unilateral, scaly, pruritic Plaques or Papules in a linear pattern
  2. Red, brown or purple lesions (or may be Skin Colored)
  • Management
  1. No definitive treatment and often refractory to therapy
  2. Potent Topical Corticosteroids (e.g. Fluocinonide ointment)
  3. Tacrolimus
  4. Surgical excision
  5. Carbon dioxide laser therapy
  • References
  1. Mitchell (2023) Am Fam Physician 108(3): 301-2 [PubMed]