• See Also
  1. ACE Inhibitor
  • Indications
  1. See ACE Inhibitor
  • Mechanism
  1. See ACE Inhibitor
  2. Non-sulfhydryl Angiotensin Converting Enzyme (ACE) inhibitor
  3. Trandolapril is a prodrug, converted to its active form Trandolaprilat in the liver via de-esterification
  • Dosing
  • Adults
  1. Adequate 24 hour Blood Pressure control may require twice daily dosing
  2. Hypertension
    1. Start 1 mg orally daily or divided twice daily
      1. Start 0.5 mg/day in renal dysfunction or comorbid Diuretic use
    2. Target 2 to 4 mg orally daily
  3. Congestive Heart Failure (CHF) or post-Myocardial Infarction
    1. Start 0.5 to 1 mg orally daily
    2. Titrate to target 4 mg orally daily
  4. Maximum: 8 mg/day (but no benefit above 4 mg/day)
  • Supplied
  1. Available as generic scored tablet (1 mg) and unscored tablet (2 and 4 mg)
  • Metabolism
  1. Excretion 66% hepatic and 33% renal
  • Adverse Effects
  1. See ACE Inhibitor
  • Safety
  1. See ACE Inhibitor
  2. Pregnancy Category X
  3. Avoid in Lactation
  • Resources
  1. Trandolapril (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bcaffc12-69af-46a8-a092-b3f66a0508d5
  • References
  1. (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia