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Perindopril

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Perindopril, Aceon

  • See Also
  1. ACE Inhibitor
  • Indications
  1. See ACE Inhibitor
  • Mechanism
  1. See ACE Inhibitor
  2. Non-sulfhydryl Angiotensin Converting Enzyme (ACE) inhibitor
  3. Perindopril is a prodrug, converted to its active form Perindoprilat via hydrolysis
  • Dosing
  1. Adequate 24 hour Blood Pressure control may require twice daily dosing
  2. Hypertension
    1. Start 4 mg orally daily or divided twice daily
      1. Start at 2 mg/day in renal dysfunction or concurrent Diuretic use
    2. Target 4 to 8 mg/day
  3. Coronary Artery Disease secondary prevention
    1. Start 4 mg orally daily for 2 weeks
    2. May increase after 2 weeks to 8 mg/day
  4. Congestive Heart Failure (not FDA approved)
    1. Start 2 mg orally daily
    2. Maximum 16 mg/day
  5. Maximum 16 mg/day
  • Supplied
  1. Available as generic unscored tablets (2, 4, 8 mg)
  • Metabolism
  1. Primarily renal metabolism
  • Adverse Effects
  1. See ACE Inhibitor
  • Safety
  1. See ACE Inhibitor
  2. Pregnancy Category X
  3. Avoid in Lactation
  • Resources
  1. Perindopril (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cbc5b3c3-4d2c-4fa0-adbb-8ddf42e881c5
  • References
  1. (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia