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Phenoxybenzamine

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Phenoxybenzamine, Dibenzyline

  • See Also
  1. Alpha Adrenergic Receptor Blocker
  2. Phentolamine
  3. Hypertensive Crisis
  4. Pheochromocytoma
  • Indications
  1. Hypertensive Crisis of Pheochromocytoma
    1. Not indicated in routine benign Hypertension
  • Mechanism
  1. Synthetic dibenzamine Alpha Adrenergic Antagonist at post-synaptic Adrenergic Receptors (alpha-1 and alpha-2)
  2. Binding results in non-selective, irreversible alkylation of the Alpha Adrenergic Receptor
  3. Causes Smooth Muscle relaxation, blocking Vasoconstriction and vasospasm
  • Dosing
  • Adults
  1. Start 10 mg orally twice daily
  2. Titrate to typical dose 20 to 40 mg orally twice daily
  3. Maximum total daily dose: 120 mg/day
  • Dosing
  • Children (Not FDA approved)
  1. Start 0.2 mg/kg/day (up to 20 mg/day or 10 mg/dose) divided twice daily orally
  2. May titrate 0.4 to 1.2 mg/kg/day up to 20 to 40 mg orally twice daily
  • Adverse Effects
  1. Symptomatic Hypotension
    1. Observe after dosing
  2. Reflex Tachycardia
  3. Possibly carcinogenic
  • Safety
  1. Pregnancy Category C
  2. Unknown Safety in Lactation
  • Resources
  1. Phenoxybenzamine Capsule (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=037202a5-e08b-4f9d-9df8-a6dd25027748