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Moexipril

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Moexipril, Univasc

  • See Also
  1. ACE Inhibitor
  • Indications
  1. See ACE Inhibitor
  • Mechanism
  1. See ACE Inhibitor
  2. Non-sulfhydryl Angiotensin Converting Enzyme (ACE) inhibitor
  3. Moexipril is a prodrug, converted to its active form Moexiprilat via hydrolysis
  • Dosing
  1. Adequate 24 hour Blood Pressure control may require twice daily dosing
  2. Take one hour before meals
  3. Hypertension
    1. Start 7.5 mg orally daily
      1. Start 3.75 mg orally daily in renal dysfunction
    2. Target 7.5 to 30 mg orally daily or divided twice daily
    3. Maximum 30 mg/day (15 mg/day in renal dysfunction)
  • Supplied
  1. Available as generic scored tablets (7.5, 15 mg)
  • Metabolism
  1. Primarily hepatic metabolism
  • Adverse Effects
  1. See ACE Inhibitor
  • Safety
  1. See ACE Inhibitor
  2. Pregnancy Category X
  3. Avoid in Lactation
  • Resources
  1. Moexipril (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5d4078f3-b621-475f-a4e6-005de2e62b32
  • References
  1. (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia