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Candesartan

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Candesartan, Atacand

  • See Also
  1. Angiotensin Receptor Blocker
  2. Hypertension
  3. Congestive Heart Failure
  • Indications
  1. See Angiotensin Receptor Blocker
  2. Hypertension
  3. Migraine Headache Prophylaxis (not FDA approved)
    1. Messina (2020) J Neurol 267(11):3243-47 +PMID: 32542525 [PubMed]
  • Contraindications
  1. See Angiotensin Receptor Blocker
  2. Glomerular Filtration Rate (GFR) <30 ml/min/1.73m2
  • Mechanism
  1. See Angiotensin Receptor Blocker
  • Dosing
  • Adults
  1. Hypertension
    1. Start 16 mg orally daily
      1. Start 8 mg daily with concurrent Diuretic, elderly or GFR 30 to 60 ml/min/1.73m2
    2. Maximum 32 mg/day
  2. Congestive Heart Failure
    1. Start 4 mg orally daily
    2. May double dose every 2 weeks as needed
    3. Maximum 32 mg/day
  • Dosing
  • Children
  1. Hypertension
    1. Age 1 to 5 years
      1. Start 0.2 mg/kg oral suspension
      2. Target 0.05 to 0.4 mg/kg/day
    2. Age 6 to 16 years and weight <50 kg
      1. Start 4 to 8 mg/day
      2. Target 4 to 16 mg/day
    3. Age 6 to 16 years and weight >50 kg
      1. Start 8 to 16 mg/day
      2. Target 4 to 32 mg/day
    4. Maximum: 0.4 mg/kg/day up to 32 mg
  • Adverse Effects
  1. See Angiotensin Receptor Blocker
  • Safety
  1. See Angiotensin Receptor Blocker
  2. Pregnancy Category X
  3. Unknown Safety in Lactation
  • Resources
  1. Candesartan (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e4100232-a25d-4468-9057-af7e66205154
  • References
  1. (2018) Presc Lett, Resource #340901, Angiotensin Receptor Blocker (ARB) Antihypertensive Dose Comparison
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia