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Betaxolol

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Betaxolol, Kerlone ( C0678122)

  • See Also
  1. Beta Blocker
  • Indications
  1. See Beta Blocker
  2. Hypertension
  • Mechanism
  1. See Beta Adrenergic ReceptorAntagonist
  2. Selective Beta Antagonist that primarily inhibits B1 activity by blocking B1 Receptors
    1. Reduces Myocardial Contractility, Blood Pressure, myocardial oxygen demand
    2. Also Antiarrhythmic and slows ventricular response in Atrial Fibrillation
  3. Contrast with non-selective Beta Blockers (e.g. Propranolol)
    1. Non-selective Beta Blockers also act at B2 Receptors (bronchoconstriction) and B3 Receptors (block lipolysis)
  • Adverse Effects
  1. See Beta Blocker
  • Drug Interactions
  1. See Beta Blocker
  • Metabolism
  1. Bioavailability 90%
    1. Low first pass hepatic metabolism
  2. Primarily excreted by the liver
  3. Lipophilic
  • Dosing
  1. Start: 10 mg orally daily
    1. Start at 5 mg in older patients or with renal Impairment
  2. Maximum: 20 mg/day
  • Safety
  1. Pregnancy Category C
  2. Unknown Safety in Lactation
  • Resources
  1. Betaxolol (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e198244d-fda3-4015-8c01-390f3f88e238
  • References
  1. (2019) Presc Lett, Resource #350503, Comparison of Oral Beta Blockers
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia