Pharm

Benazapril

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Benazapril, Lotensin

  • See Also
  1. ACE Inhibitor
  • Indications
  1. See ACE Inhibitor
  2. Hypertension
  3. Congestive Heart Failure
  • Mechanism
  1. See ACE Inhibitor
  2. Carboxyl-containing Angiotensin-converting enzyme (ACE) inhibitor
  3. Benazapril is a prodrug, converted to its active form benazeprilat in the liver
  • Dosing
  • Adults
  1. Adequate 24 hour control may require divided dosing twice daily
  2. Hypertension
    1. Start 10 mg orally daily
      1. Start at 5 mg orally daily in elderly, Diuretic use, GFR <30
      2. Start at 5 mg in Congestive Heart Failure (CHF)
    2. Target 20-40 mg/day
  3. Maximum: 80 mg/day (40 mg/day in CHF)
  4. Renal Dosing
    1. GFR <30 ml/min: Start at 5 mg
  • Dosing
  • Children (age >=6 years old)
  1. Contraindicated if GFR <30 ml/min or age <6 years old
  2. Hypertension
    1. Start 0.2 mg/kg/day up to 10 mg/day
    2. Maximum: 0.6 mg/day up to 40 mg/day
  • Supplied
  1. Available as unscored generic tablets: 5, 10, 20 and 40 mg
  • Metabolism
  1. Primarily renal excretion (as benzeprilat)
  • Adverse Effects
  1. See ACE Inhibitor
  • Safety
  1. See ACE Inhibitor
  2. Pregnancy Category X
  3. Avoid in Lactation
  • Resources
  1. Benazapril (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a216253b-27cb-42ef-b5a8-67fb05aafb88
  • References
  1. (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia