Surgery

Interstitial Brachytherapy for Prostate Cancer

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Interstitial Brachytherapy for Prostate Cancer, Prostate Seed Implant Radiotherapy

  • Indications
  1. Localized Prostate Cancer (Stages A to C)
  • Technique
  1. Permanent radioactive seed implants into Prostate
    1. Iodine 125
    2. Palladium 103
  2. Seeds precisely geometric arranged by computer
  • Efficacy
  1. Appears effective as conventional Prostate Radiotherapy
  • Advantages over External Beam Prostate Radiotherapy
  1. Higher radiation dose with less adverse effects
  2. Avert daily Radiation Therapy for 4 to 6 weeks
  • Adverse Effects
  1. Acute irritative uropathy for first 3 months
    1. Urinary urgency
    2. Dysuria and Pelvic Pain
    3. Urinary Frequency
  2. Urinary Incontinence (1%)
  3. Impotence (30 to 50%)
  4. Rectal irritation (3 to 10%)
    1. Diarrhea
    2. Stool Urgency
    3. Tenesmus
    4. Rectal Bleeding
  • References
  1. Middleton (1996) CA Cancer J Clin 46(4):249-53 [PubMed]
  2. Naitoh (1998) Am Fam Physician 57(7):1531-9 [PubMed]
  3. Narayan (April, 1996) Hospital Physician, p.37-50
  4. Porter (1995) CA Cancer J Clin 45(3):165-78 [PubMed]
  5. Williams (1996) Postgrad Med 100(3): 105-20 [PubMed]