ID
Malacoplakia
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Malacoplakia
Epidemiology
Rare
Pathophysiology
Secondary
Granuloma
tous inflammatory reaction to chronic genitourinary infection in
Immunocompromised
patients
Associated with chronic infections (e.g.
E. coli
and other
Gram Negative
s)
Infections may involve the
Kidney
and
Retroperitoneum
,
Bladder
,
Prostate
, ureter,
Kidney
, and female genital tract
Labs
Hallmark finding is foamy histiocytes with
Basophil
ic inclusions (Michaelis-Gutmann bodies)
Management
Treated with antibiotics and surgical excision, correction of
Immunosuppression
Antibiotic management with
Ciprofloxacin
or trimethoprim-sulfamethoxazole
Concurrent management with
Bethanechol
chloride which improves antibiotic efficacy
References
Dong (2015) Urol Case Rep 3(1): 6–8 [PubMed]
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714269/
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