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Prostate Cancer Histologic grading

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Prostate Cancer Histologic grading, Gleason Grading, Gleason Score

  • See Also
  1. Prostate Cancer
  • Grading
  • Gleason Grade
  1. Score
    1. Grade dominant Prostate tumor on scale 1 to 5
    2. Grade other histologic patterns on scale 1 to 5
    3. Sum 2 grades for total score of 2 to 10 for tumor
  2. Interpretation: Prostate Cancer histology
    1. Grade 2 suggests highly differentiated tumor (best)
    2. Grade 10 suggests undifferentiated tumor (worst)
  • Grading
  • Grade Group (GG)
  1. Score
    1. Grade Group 1: Equivalent to Gleason Score of 6 (3+3)
    2. Grade Group 2: Equivalent to Gleason Score of 7 (3+4)
    3. Grade Group 3: Equivalent to Gleason Score of 7 (4+3)
    4. Grade Group 4: Equivalent to Gleason Score of 8 (4+4)
    5. Grade Group 5: Equivalent to Gleason Score of 9 or 10 (4+5 or 5+5)
  2. Interpretation
    1. GG1 lesions are associated with very low mortality
    2. Most Prostate Cancer Management is focused on GG2 and higher
  • Reference
  1. Wilson (1991) Harrison's Internal Medicine, p. 1630
  2. Pierorazio (2013) BJU Int 111(5): 753-60 +PMID: 23464824 [PubMed]