Derm
Angiokeratoma
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Angiokeratoma
, Angiokeratoma of the Glans Penis, Fabry Disease, Angiokeratoma of Fordyce
See Also
Penile Lesion
Epidemiology
Prevalence
: <1% (U.S.)
More common in white patients
Age of onset >40 years
Symptoms
Typically asymptomatic
May rarely bleed or be pruritic
Signs
Red-blue, benign vascular
Papule
s
Typically 1-2 mm in size (up to 6 mm)
Distribution
Clustered on the glans penis, often linear along the margin
May occur on
Scrotum
, groin, thighs, and abdominal wall
Red Flag: Lesions on the penile shaft, suprapubic region or
Sacrum
Suggests Fabry Disease and requires referral (see below)
Differential Diagnosis
Pearly Penile
Papule
s
Penile Cancer
Fabry Disease (
Lysosomal Storage Disease
)
May present with Angiokeratomas on the penile shaft, suprapubic region or
Sacrum
Fabry Disease is associated with
Renal Failure
,
Cardiomyopathy
,
Hypertension
,
Anhidrosis
and neuropathic pain
Requires urgent
Consultation
Management
Symptomatic Cases (e.g. Bleeding)
Electrocautery
Cryotherapy
Laser ablation
Surgical excision
References
Leis-Dosil (2007) Dermatol Online J 13(2): 19 [PubMed]
Teichman (2010) Am Fam Physician 81(2): 167-74 [PubMed]
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