Pharm

Zaleplon

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Zaleplon, Sonata

  • See Also
  1. Insomnia
  2. Benzodiazepine Receptor Agonist
  • Mechanism
  1. Nonbenzodiazepine Hypnotic Agent (Benzodiazepine Receptor Agonist)
  • Indication
  1. Insomnia
  2. Consider for early awakening in middle of night
  • Pharmacokinetics
  1. Half-Life: 1 hour
  2. Peak Onset: 30 minutes
  3. Duration
    1. Typically 4 hours, but may be as long as 6-8 hour
  4. Metabolized by CYP450 3A4
  • Dosing
  1. Start: 5-10 mg orally at bedtime
  2. Elderly: 5 mg orally at bedtime
  3. Maximum: 20 mg orally at bedtime
  • Adverse Effects
  1. See Nonbenzodiazepine Hypnotic Agent for common effects
  2. Altered color Perception
  • Advantages
  1. See Nonbenzodiazepine Hypnotic Agent
  2. Effective in middle of night awakening
    1. Can take mid-way through sleep period
  • Resources
  1. Zaleplon (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=57a1a11d-7767-4caf-b98a-75d7561d9165