Pharm

Tranylcypromine

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Tranylcypromine, Parnate

  • See Also
  1. MAO Inhibitor
  2. Antidepressant
  • Precautions
  1. See MAO Inhibitors
  2. Follow low tyramine diet and avoid Sympathomimetics, Serotonergic Medications
  3. MAO Inhibitors are not first-line agents for Mood Disorders
  • Indications
  1. Refractory Major Depression
  1. Start: 10 mg orally three times daily
  2. Titrate by 10 mg/day increases every 1 to 3 weeks as needed and as tolerated
  3. Maximum: 60 mg per day (30 mg orally twice daily)
  • Adverse Effects
  1. See MAO Inhibitor
  • Drug Interactions
  1. See MAO Inhibitors
  • Mechanism
  1. See MAO Inhibitor
  2. Tranylcypromine is a non-hydrazine MAO Inhibitor which irreversibly blocks MAO nonselectively (MAO-A and MAO-B are both affected)
  • Resources
  1. Tranylcypromine (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b72d8187-dfcc-4ea0-b5e9-c0be95b69a27
  • References
  1. (2023) Med Lett Drugs Ther 62(1592): 25-32
  2. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 36-7
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia